methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

Base Information

Chemical Name:methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester
CAS No.:1313537-97-1
Molecular Formula:C₂₃H₂₇NO₅S₂
Molecular Weight:461.603
Hs Code.:

Synonyms:methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

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Chemical Property of methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

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Technology Process of methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

There total 6 articles about methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1313537-90-4
2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethanol

: 124-63-0
methanesulfonyl chloride

: 1313537-97-1
methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.tet.2011.04.089

Reference yield:

: C₁₈H₂₁NO₄S

: 1313537-97-1
methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / acetone / 0.33 h / 20 °C / Inert atmosphere

2.1: dichloromethane / 3 h / Inert atmosphere; Reflux

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

3.2: 0.25 h / 20 °C / Inert atmosphere

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

4.2: Inert atmosphere; Cooling with ice

5.1: pyridine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With pyridine; lithium aluminium tetrahydride; Jones reagent; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane; acetone; 1.1: Jones oxidation / 2.1: Wittig reaction;
DOI:10.1016/j.tet.2011.04.089

Reference yield:

: 1219711-47-3
(1-benzenesulfonyl-4-methoxy-4-phenylpiperidin-3-ylidene)acetic acid ethyl ester

: 1313537-97-1
methanesulfonic acid 2-(2-allyl-1-benzenesulfonyl-4-phenyl-1,2,5,6-tetrahydropyridin-3-yl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.33 h / Inert atmosphere; Reflux

1.2: 0.25 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice; Inert atmosphere

2.2: Inert atmosphere; Cooling with ice

3.1: pyridine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

With pyridine; lithium aluminium tetrahydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.04.089