Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

Base Information

Chemical Name:Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride
CAS No.:917885-96-2
Molecular Formula:C₃₀H₃₀Cl₂N₄O₅*ClH
Molecular Weight:633.959
Hs Code.:

Synonyms:Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

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Chemical Property of Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

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Technology Process of Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

There total 11 articles about Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1029395-39-8
Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-formyl-N-methylaminomethyl)quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester

: 917885-96-2
Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

Guidance literature:: Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-formyl-N-methylaminomethyl)quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester; With acetyl chloride; isopropyl alcohol; at 10 ℃; for 1h;

In Isopropyl acetate; isopropyl alcohol; at 70 ℃; for 24h;

Reference yield:

: 857870-47-4
4-amino-Nα-(2,6-dichlorobenzoyl)-L-phenylalanine isopropyl ester

: 917885-96-2
Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: N,N-dimethyl-formamide / 20 - 80 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

4.1: triethylamine / palladium diacetate / water; N,N-dimethyl-formamide / 11 h / 70 °C

5.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

5.2: 1 h / 0 °C

6.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

7.1: tetrahydrofuran; acetonitrile / 10 h / 20 °C

8.1: hydrogenchloride / acetone / 72.5 h / 5 - 60 °C

With hydrogenchloride; chloroformic acid ethyl ester; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 401906-14-7
Nα-(2,6-dichlorobenzoyl)-4-nitro-L-phenylalanine

: 917885-96-2
Nα-(2,6-dichlorobenzoyl)-4-{1-methyl-6-(N-methylamino-methyl)-quinazoline-2,4[1H,3H]-dion-3-yl}-L-phenylalanine isopropyl ester hydrochloride

Guidance literature:: Multi-step reaction with 10 steps

1.1: sulfuric acid / tetrahydrofuran / 120 h / 50 °C

2.1: hydrogen / 3percent Pt-S/C / tetrahydrofuran; isopropyl alcohol / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 20 - 80 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

6.1: triethylamine / palladium diacetate / water; N,N-dimethyl-formamide / 11 h / 70 °C

7.1: chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

7.2: 1 h / 0 °C

8.1: trichlorophosphate / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 - 20 °C

9.1: tetrahydrofuran; acetonitrile / 10 h / 20 °C

10.1: hydrogenchloride / acetone / 72.5 h / 5 - 60 °C

With hydrogenchloride; sulfuric acid; hydrogen; chloroformic acid ethyl ester; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trichlorophosphate; palladium diacetate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; acetonitrile;