Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Base Information

Chemical Name:Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester
CAS No.:309967-68-8
Molecular Formula:C₄₆H₅₁N₄O₉P
Molecular Weight:834.906
Hs Code.:

Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Synonyms:Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Chemical Property of Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

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Technology Process of Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

There total 4 articles about Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 309967-66-6
5'-O-(4,4'-dimethoxytrityl)-3-N-benzoyl-2'-deoxyuridine

: 309967-68-8
Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;
DOI:10.1021/jo991097e

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 309967-68-8
Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (Me₃Si)2N / acetonitrile / 1 h / Heating

1.2: Na₂CO₃; Bu₄NBr / CH₂Cl₂ / 3 h

1.3: 92 percent / TFA / methanol / 0.33 h

2.1: 99 percent

3.1: 93 percent / iPr₂NEt / CH₂Cl₂ / 1 h

With (Me₃Si)2N; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 1.1: silylation / 1.2: Acylation / 1.3: desilylation / 2.1: tritylation / 3.1: Substitution;
DOI:10.1021/jo991097e

Reference yield:

: 98-88-4
benzoyl chloride

: 309967-68-8
Diisopropyl-phosphoramidous acid (2R,3S,5R)-5-(3-benzoyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: (Me₃Si)2N / acetonitrile / 1 h / Heating

1.2: Na₂CO₃; Bu₄NBr / CH₂Cl₂ / 3 h

1.3: 92 percent / TFA / methanol / 0.33 h

2.1: 99 percent

3.1: 93 percent / iPr₂NEt / CH₂Cl₂ / 1 h

With (Me₃Si)2N; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 1.1: silylation / 1.2: Acylation / 1.3: desilylation / 2.1: tritylation / 3.1: Substitution;
DOI:10.1021/jo991097e