N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Base Information

Chemical Name:N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide
CAS No.:433288-70-1
Molecular Formula:C₃₆H₄₂N₆O₆Si
Molecular Weight:682.852
Hs Code.:

<i>N</i>-(9-{5-(<i>tert</i>-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(<i>N</i>-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9<i>H</i>-purin-6-yl)-benzamide

Synonyms:N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Chemical Property of N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

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Technology Process of N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

There total 10 articles about N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 212061-63-7
N⁶-benzoyl-5'-O-(tert-butyldiphenylsilyl)-2'-O-{2-[(methyleneamino)oxy]ethyl}adenosine

: 433288-70-1
N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: With pyridinium p-toluenesulfonate; sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jo0103975

Reference yield:

: 98-88-4
benzoyl chloride

: 433288-70-1
N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine N-oxide; OsO₄ / dioxane / 3 h

2: NaIO₄ on SiO₂ / CH₂Cl₂ / 0.5 h / 20 °C

3: 4.31 g / pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 8 h / 20 °C

4: 91.5 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

5: N-methylhydrazine / CH₂Cl₂ / 0 °C

6: 2.47 g / methanol; H₂O / 20 °C

7: pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 20 °C

With sodium periodate; osmium(VIII) oxide; pyridinium p-toluenesulfonate; sodium cyanoborohydride; 4-methylmorpholine N-oxide; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 5: Mitsunobu reaction;
DOI:10.1021/jo0103975

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 433288-70-1
N-(9-{5-(tert-butyl-diphenyl-silanyloxymethyl)-4-hydroxy-3-[2-(N-methyl-aminooxy)-ethoxy]-tetrahydro-furan-2-yl}-9H-purin-6-yl)-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: N-methylmorpholine N-oxide; OsO₄ / dioxane / 3 h

2: NaIO₄ on SiO₂ / CH₂Cl₂ / 0.5 h / 20 °C

3: 4.31 g / pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 8 h / 20 °C

4: 91.5 percent / PPh₃; DEAD / tetrahydrofuran / 20 °C

5: N-methylhydrazine / CH₂Cl₂ / 0 °C

6: 2.47 g / methanol; H₂O / 20 °C

7: pyridinium p-toluenesulfonate; NaBH₃CN / methanol / 20 °C

With sodium periodate; osmium(VIII) oxide; pyridinium p-toluenesulfonate; sodium cyanoborohydride; 4-methylmorpholine N-oxide; triphenylphosphine; methylhydrazine; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; 5: Mitsunobu reaction;
DOI:10.1021/jo0103975