4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI)

Base Information

Chemical Name:4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI)
CAS No.:118916-78-2
Molecular Formula:C₆H₉NO₃
Molecular Weight:143.142
Hs Code.:
Mol file:118916-78-2.mol

Synonyms:4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI)

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI)

Chemical Property:

PSA：47.89000
LogP:-0.58940

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI)

There total 5 articles about 4-Oxazolecarboxylicacid,4,5-dihydro-5-methyl-,methylester,(4S-cis)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 82679-55-8
D-threonine methyl ester

: 53216-07-2,53229-11-1,58861-76-0,62211-72-7,62211-73-8,104320-71-0,118916-74-8,118916-78-2
(4R,5S)-5-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1021/ja801383f

Reference yield:

: 39687-95-1
isocyanoacetic acid methyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 53229-11-1
5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 53216-07-2,53229-11-1,58861-76-0,62211-72-7,62211-73-8,104320-71-0,118916-74-8,118916-78-2
(4R,5S)-5-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: bis(cyclohexylisocyanide)gold(I) tetrafluoroborate; chiral "ferrocenylbisphosphine" compound; In dichloromethane; at 25 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1016/S0040-4020(01)88870-0

Reference yield:

: 39687-95-1
isocyanoacetic acid methyl ester

: 75-07-0,9002-91-9
acetaldehyde

: 53229-11-1
5-methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 53216-07-2,53229-11-1,58861-76-0,62211-72-7,62211-73-8,104320-71-0,118916-74-8,118916-78-2
(4R,5S)-5-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

: 53216-07-2,53229-11-1,58861-76-0,62211-72-7,62211-73-8,104320-71-0,118916-74-8,118916-78-2
(4S,5S)-5-Methyl-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: bis(cyclohexyl isocyanide)gold(I) tetrafluoroborate*(R)-N-methyl-N-<2-(1-piperidino)ethyl>-1-<(S)-1',2-bis(diphenylphosphino)ferrocenyl>ethylamine; In dichloromethane; at 25 ℃; for 15h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; trans/cis ratio 85/15, ee = 85percent;
DOI:10.1016/S0040-4039(00)82336-9