7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Name:7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one
CAS No.:146449-16-3
Molecular Formula:C₁₄H₁₉N₃O₂S
Molecular Weight:293.39
Hs Code.:

Synonyms:7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Chemical Property of 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

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Technology Process of 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

There total 7 articles about 7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 15781-70-1
malonic acid bis-(2,4,6-trichloro-phenyl) ester

: 118313-94-3
5-[2-(4-Methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazol-2-ylamine

: 146449-16-3
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: In n-heptane; at 140 - 150 ℃; for 2h;
DOI:10.1248/cpb.40.2391

Reference yield:

: 127180-76-1,42778-89-2,191113-70-9
ethyl 4-methylcyclohexylideneacetate

: 146449-16-3
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

2: LiAlH₄ / tetrahydrofuran

3: PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

4: 95 percent / dimethylsulfoxide

5: 16.4 percent / CF₃COOH

6: 82 percent / heptane / 2 h / 140 - 150 °C

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide;
DOI:10.1248/cpb.40.2391

Reference yield:

: 589-92-4
1-methylcyclohexan-4-one

: 146449-16-3
7-Hydroxy-2-[2-(4-methyl-cyclohexyl)-ethyl]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one

Guidance literature:: Multi-step reaction with 7 steps

1: 78 percent / NaH / benzene

2: 97 percent / H₂ / 5percent Pd/C / ethanol / 760 Torr

3: LiAlH₄ / tetrahydrofuran

4: PBr₃ / diethyl ether; diethyl ether / 16 h / Ambient temperature

5: 95 percent / dimethylsulfoxide

6: 16.4 percent / CF₃COOH

7: 82 percent / heptane / 2 h / 140 - 150 °C

With lithium aluminium tetrahydride; hydrogen; phosphorus tribromide; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; n-heptane; dimethyl sulfoxide; benzene;
DOI:10.1248/cpb.40.2391