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15781-70-1

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15781-70-1 Usage

Uses

Bis(2,4,6-trichlorophenyl) Malonate can be used as novel orally active inhibitor of HLE to treat chronic obstructive pulmonary diseases, asthma, emphysema, cystic fibrosis and several inflammatory diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 15781-70-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,7,8 and 1 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 15781-70:
(7*1)+(6*5)+(5*7)+(4*8)+(3*1)+(2*7)+(1*0)=121
121 % 10 = 1
So 15781-70-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H6Cl6O4/c16-6-1-8(18)14(9(19)2-6)24-12(22)5-13(23)25-15-10(20)3-7(17)4-11(15)21/h1-4H,5H2

15781-70-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Bis(2,4,6-trichlorophenyl) malonate

1.2 Other means of identification

Product number -
Other names bis(2,4,6-trichlorophenyl) propanedioate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15781-70-1 SDS

15781-70-1Relevant articles and documents

An activated coumarin-enamine Michael acceptor for CN-

Davis, Aaron B.,Lambert, Rachel E.,Fronczek, Frank R.,Cragg, Peter J.,Wallace, Karl J.

, p. 4678 - 4683 (2014)

Two coumarin-enamine chemodosimeters have been synthesized in three steps. They have been shown to selectively detect the cyanide ion with a fluorescent response (t1/2 = 20 s) and a limit of detection approximately 4.2 ppb in DMSO. The X-ray crystal structure of the thermodynamically stable E-(keto) enamine isomer of one compound was obtained and exhibited offset π-stacking. This journal is

Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine- 7-carboxamides as PI3Kβ/δ inhibitors for the treatment of PTEN-deficient tumours

Barlaam, Bernard,Cosulich, Sabina,Degorce, Sébastien,Fitzek, Martina,Giordanetto, Fabrizio,Green, Stephen,Inghardt, Tord,Hennequin, Laurent,Hancox, Urs,Lambert-Van Der Brempt, Christine,Morgentin, Rémy,Pass, Sarah,Plé, Patrick,Saleh, Twana,Ward, Lara

, p. 3928 - 3935 (2014)

Starting from TGX-221, we designed a series of 9-(1-anilinoethyl)-2- morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as potent and selective PI3Kβ/δ inhibitors. Structure-activity relationships and structure-property relationships around the aniline and the amide substituents are discussed. We identified compounds 17 and 18, which showed profound pharmacodynamic modulation of phosphorylated Akt in the PC3 prostate tumour xenograft, after a single oral dose. Compound 17 also gave significant inhibition of tumour growth in the PC3 prostate tumour xenograft model after chronic oral dosing.

Design and synthesis of a novel colorimetric fluorescent probe for the selective detection of sulfur dioxide in SH-SY5Y neuroblastoma cells and its applications in traditional Chinese medicines

Yang, Lili,Liu, Mofan,Sheng, Kangjia,Li, Xiaolu,Du, Junli,Ning, Yaoyao,Wang, Xiaoqing,Li, Jianli,Zhang, Yongmin,Wu, Shaoping

, p. 4188 - 4195 (2019)

Sulfur fumigation has attracted extensive attention as one of the important post-harvest processing methods for some traditional Chinese medicines (TCMs) in the last decade. However, sulfur fumigation has recently emerged as a controversial topic due to its potential detrimental effects on the safety and efficacy of TCMs as some sulfur-fumigated TCMs contain numerous sulfur dioxide derivatives; moreover, high levels of sulfur dioxide derivatives can cause some diseases and dangerous environmental pollution. In this study, a DTCC probe with a fast response time, low limit of detection and a high fluorescence quantum yield was designed and synthesized to detect SO2 derivatives based on the coumarin-thiophene dye, which was fused with a coumarin moiety and 2-thiophenecarboxaldehyde. The probe DTCC exhibited a fast response time (less than 10 s), satisfactory selectivity for SO2 derivatives in the presence of other ROS and excellent sensitivity for SO2 derivatives with a low limit of detection (0.23 μM) as well as a wide linear range (0-100 μM). Furthermore, the probe DTCC was successfully applied in fluorescence imaging in SH-SY5Y neuroblastoma cells with excellent membrane permeability and stability. It was also employed in monitoring the total SO2 derivatives in several real TCM samples. These results illustrate that the probe DTCC has an excellent capability for monitoring SO2 derivatives in living cells and real TCM samples.

SUBSTITUTED BICYCLE HETEROCYCLIC DERIVATIVES USEFUL AS ROMK CHANNEL INHIBITORS

-

Page/Page column 152, (2018/06/06)

Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Deep red emitting triphenylamine based coumarin-rhodamine hybrids with large Stokes shift and viscosity sensing: Synthesis, photophysical properties and DFT studies of their spirocyclic and open forms

Kothavale, Shantaram,Jadhav, Amol G.,Sekar, Nagaiyan

, p. 329 - 341 (2016/11/23)

We designed and synthesized triphenylamine based and coumarin fused rhodamine hybrid dyes and characterized using 1H, 13C NMR and HR-LCMS analysis. Both the newly synthesized hybrid dyes were found to show red shifted absorption as well as emissions and large Stokes shift (40–68 nm) as compared to the small Stokes shift (25–30 nm) of reported dyes Rhodamine B and 101. Photophysical properties of these dyes were studied in different solvents and according to the solvents acidity or basicity they preferred to remain in their spirocyclic or open form in different ratio. We studied the spirocyclic as well as open form derivatives of these dyes for their viscosity sensitivity in three different mixture of solvents i.e. polar-protic [EtOH-PEG 400], polar-aprotic [toluene-PEG 400] and non-polar-aprotic [toluene-paraffin]. They are found to show very high viscosity sensitivity in polar-protic mixture of solvents [EtOH-PEG 400] and hence concluded that both polarity as well as viscosity factor worked together for the higher emission enhancement rather than only viscosity factor. As these dyes showed very high viscosity sensitivity in their spirocyclic as well as open form, they can be utilized as viscosity sensors in visible as well as deep red region. We also correlated our experimental finding theoretically by using Density Functional theory computations.

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