3-METHOXYPHENYLGLYOXAL HYDRATE

Base Information

• Chemical Name: 3-METHOXYPHENYLGLYOXAL HYDRATE
• CAS No.: 118888-62-3
• Molecular Formula: C9H10 O3
• Molecular Weight: 166.177
• Mol file: 118888-62-3.mol

Synonyms:3-METHOXYPHENYLGLYOXAL HYDRATE;3-METHOXYPHENYLGLYOXAL HYDRATE, 95+%

Chemical Property of 3-METHOXYPHENYLGLYOXAL HYDRATE

Chemical Property:

• Boiling Point: 289.5±25.0 °C(Predicted)
• PKA: 11.02±0.41(Predicted)
• PSA: 66.76000
• Density: 1.252±0.06 g/cm3(Predicted)
• LogP: 0.18860

Purity/Quality:

98%min ^*data from raw suppliers

2,2-Dihydroxy-1-(m-tolyl)ethanone 95+% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Irritant:

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHOXYPHENYLGLYOXAL HYDRATE

There total 1 articles about 3-METHOXYPHENYLGLYOXAL HYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methylacetophenone (585-74-0) → m-tolylglyoxal (118888-62-3)

Guidance literature:

With selenium(IV) oxide; In 1,4-dioxane; water; Reflux;

DOI:10.1002/ejoc.201501423

Reference yield: 94.0%

m-tolylglyoxal (118888-62-3) + tert-butyl alcohol (75-65-0) → (S)-tert-butyl α-hydroxy-α-(3-methylphenyl)acetate (1361384-66-8)

Guidance literature:

With iron(III) chloride; C₄₃H₆₄N₄O₄; oxygen; In dichloromethane; at 30 ℃; for 24h; enantioselective reaction; Molecular sieve;

DOI:10.1039/c5cc04213e

Reference yield: 89.0%

4-hydroxy[1]benzopyran-2-one (1076-38-6,92395-12-5) + m-tolylglyoxal (118888-62-3) + 4-chloro-phenol (106-48-9,82344-39-6) → 3-(5-chloro-2-(m-tolyl)benzofuran-3-yl)-4-hydroxy-2H-chromen-2-one

Guidance literature:

With iron(III) chloride; In 1,2-dichloro-ethane; at 84 ℃; for 1h; Green chemistry;

DOI:10.1039/c8ob00942b

upstream raw materials:

3-Methylacetophenone

Downstream raw materials:

3,3,6,6-Tetramethyl-9-(3-methyl-benzoyl)-3,4,5,6,7,9-hexahydro-2H-xanthene-1,8-dione

4,4,8,8-Tetramethyl-1-m-tolyl-2,4,5,7,8,9-hexahydro-3H-pyrrolo[2,3,4-kl]acridin-10-one

(S)-tert-butyl α-hydroxy-α-(3-methylphenyl)acetate

isopropyl benzoylformate

Refernces

• 1、 Wu, Wangbin,Zou, Sijia,Lin, Lili,Ji, Jie,Zhang, Yuheng,Ma, Baiwei,Liu, Xiaohua,Feng, Xiaoming. "Catalytic asymmetric Meerwein-Ponndorf-Verley reduction of glyoxylates induced by a chiral N,N′-dioxide/Y(OTf)3 complex". supporting information. p. 3232 - 3235. Retrieved 2017/03/20.
• 2、 Wang, Qiang,Xu, Youwei,Yang, Xifa,Li, Yunyun,Li, Xingwei. "Naphthol synthesis: Annulation of nitrones with alkynes: Via rhodium(III)-catalyzed C-H activation". supporting information. p. 9640 - 9643. Retrieved 2017/09/01.