(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

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Chemical Name:(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one
CAS No.:1432519-22-6
Molecular Formula:C₃₄H₃₈O₄S₂
Molecular Weight:574.805
Hs Code.:

Synonyms:(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

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Chemical Property of (5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

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Technology Process of (5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

There total 5 articles about (5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1432518-88-1
2-[bis(phenylsulfanyl)methyl]benzaldehyde

: 112968-75-9,122079-41-8,122079-45-2,135041-07-5,77934-87-3
(5R)-(L-menthyloxy)-2(5H)-furanone

: 1432519-22-6
(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

Guidance literature:: 2-[bis(phenylsulfanyl)methyl]benzaldehyde; (5R)-(L-menthyloxy)-2(5H)-furanone; With n-butyllithium; diphenyl diselenide; In tetrahydrofuran; hexane; at -45 - -20 ℃; for 8h;

With benzyl bromide; tetra-(n-butyl)ammonium iodide; at -45 - -20 ℃; for 8h;
DOI:10.1039/c3ob40115d

Reference yield:

: 89-71-4
2-Methyl-benzoic acid methyl ester

: 1432519-22-6
(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / tetrachloromethane / Irradiation

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 12 h

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.33 h / -78 °C / Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice

5.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -45 - -20 °C

5.2: 8 h / -45 - -20 °C

With n-butyllithium; diphenyl diselenide; bromine; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c3ob40115d

Reference yield:

: 1432518-92-7
{2-[bis(phenylsulfanyl)methyl]phenyl}methanol

: 1432519-22-6
(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice

2.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -45 - -20 °C

2.2: 8 h / -45 - -20 °C

With n-butyllithium; diphenyl diselenide; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c3ob40115d