(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Chemical Name:(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate
CAS No.:1432519-24-8
Molecular Formula:C₃₆H₄₀O₅S₂
Molecular Weight:616.843
Hs Code.:

Synonyms:(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Chemical Property of (S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

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Technology Process of (S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

There total 6 articles about (S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1432519-22-6
(5R)-3-[(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}(hydroxy)methyl]-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2,5-dihydrofuran-2-one

: 75-36-5
acetyl chloride

: 1432519-24-8
(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 3h; Cooling with ice;
DOI:10.1039/c3ob40115d

Reference yield:

: 89-71-4
2-Methyl-benzoic acid methyl ester

: 1432519-24-8
(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: bromine / tetrachloromethane / Irradiation

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C

2.2: 12 h

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2.33 h / -78 °C / Cooling with ice

4.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice

5.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -45 - -20 °C

5.2: 8 h / -45 - -20 °C

6.1: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

With pyridine; dmap; n-butyllithium; diphenyl diselenide; bromine; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; tetrachloromethane; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1039/c3ob40115d

Reference yield:

: 1432518-92-7
{2-[bis(phenylsulfanyl)methyl]phenyl}methanol

: 1432519-24-8
(S)-{2-[bis(phenylsulfanyl)methyl]phenyl}[(5R)-5-{[(1R,2S,5R)-5-methyl-2-(propan-2-yl)cyclohexyl]oxy}-2-oxo-2,5-dihydrofuran-3-yl]methyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 12 h / 0 °C / Cooling with ice

2.1: n-butyllithium; diphenyl diselenide / hexane; tetrahydrofuran / 8 h / -45 - -20 °C

2.2: 8 h / -45 - -20 °C

3.1: dmap; pyridine / dichloromethane / 3 h / 0 °C / Cooling with ice

With pyridine; dmap; n-butyllithium; diphenyl diselenide; sulfur trioxide pyridine complex; triethylamine; In tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c3ob40115d