3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Base Information

• Chemical Name: 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂
• CAS No.: 97119-38-5
• Molecular Formula: C₄₃H₅₂N₄O₁₅S₅
• Molecular Weight: 1025.23

Synonyms:3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property of 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

Chemical Property:

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Technology Process of 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

There total 5 articles about 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

sodium acetate (127-09-3) + 1-Desamino-6-desoxy-5-O-(methylsulfonyl)-2',3,6'-tris-N-(p-tolylsulfonyl)-1,6-<(p-tolylsulfonyl)epimino>sisamin (97119-37-4) → 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-38-5)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 0.166667h;

DOI:10.1002/jlac.198519850511

Reference yield:

Sisamin (47086-84-0,68297-05-2) → 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / H₂O; dioxane / 1) from 0 deg C to room temp., 2) 2 h, 20 deg C

2: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

3: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

4: 76 percent / dimethylformamide / 0.17 h / 60 °C

With sodium hydride; potassium carbonate; In 1,4-dioxane; pyridine; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

Reference yield:

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin (97119-33-0) → 3-O-Acetyl-3-O,4-N-didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG2 (97119-38-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / pyridine; CH₂Cl₂ / 3 h / Ambient temperature

2: 32 percent / NaH / dimethylformamide / 0.5 h / 0 °C

3: 76 percent / dimethylformamide / 0.17 h / 60 °C

With sodium hydride; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/jlac.198519850511

upstream raw materials:

sodium acetate

1-Desamino-6-desoxy-5-O-(methylsulfonyl)-2',3,6'-tris-N-(p-tolylsulfonyl)-1,6-<(p-tolylsulfonyl)epimino>sisamin

Sisamin

1,2',3,6'-Tetrakis-N-(p-tolylsulfonyl)sisamin

Downstream raw materials:

3-O,4-N-Didesmethyl-5-O-(methylsulfonyl)-1,2',4,6'-tetrakis-N-(p-tolylsulfonyl)fortimicin KG₂

3-O,4-N-Didesmethylfortimicin KG₂

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