6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Base Information

Chemical Name:6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate
CAS No.:337522-97-1
Molecular Formula:C₃₈H₃₄N₂O₃
Molecular Weight:566.7
Hs Code.:

Synonyms:6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

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Chemical Property of 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

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Technology Process of 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

There total 10 articles about 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 337521-26-3
methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

: 337522-97-1
6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:: methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate; With methanol; sodium hydroxide; In tetrahydrofuran; at 60 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 1219689-97-0
(7-bromo-3-methoxynaphthalen-2-yl)methanol

: 337522-97-1
6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: manganese(IV) oxide / dichloromethane / 1 h / Reflux

2.1: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 0.5 h / 160 - 180 °C

3.1: boron tribromide / dichloromethane / 2 h / -70 - 20 °C

3.2: 0 °C

4.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

4.2: 0 °C

5.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

5.2: 0.83 h / -70 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

7.1: pyridine / 1 h / 0 °C

8.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

9.1: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 60 °C

9.2: 0 °C

With pyridine; 1H-imidazole; methanol; manganese(IV) oxide; 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; tetrabutyl ammonium fluoride; palladium diacetate; boron tribromide; hydrazine hydrate; triethylamine; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 2.1: Wolff-Kishner reduction;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 1285532-63-9
6-bromo-3-methyl-2-naphthol

: 337522-97-1
6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 0 °C

2.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

2.2: 0.83 h / -70 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4.1: pyridine / 1 h / 0 °C

5.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

6.1: methanol; sodium hydroxide / tetrahydrofuran / 2 h / 60 °C

6.2: 0 °C

With pyridine; 1H-imidazole; methanol; 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; tetrabutyl ammonium fluoride; palladium diacetate; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017