methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Base Information

Chemical Name:methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate
CAS No.:337521-26-3
Molecular Formula:C₃₉H₃₆N₂O₃
Molecular Weight:580.726
Hs Code.:

Synonyms:methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Chemical Property:

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Technology Process of methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

There total 11 articles about methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 67-56-1
methanol

: 6-[1-Hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthyl Trifluoromethanesulfonate

: 201230-82-2
carbon monoxide

: 337521-26-3
methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 14h; under 760.051 Torr;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 6-[1-Hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthyl Trifluoromethanesulfonate

: 337521-26-3
methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:

Reference yield:

: 1219689-98-1
7-bromo-3-methoxy-2-naphthaldehyde

: 337521-26-3
methyl 6-(1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl)-3-methyl-2-naphthoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrazine hydrate; potassium hydroxide / 2,2'-[1,2-ethanediylbis(oxy)]bisethanol / 0.5 h / 160 - 180 °C

2.1: boron tribromide / dichloromethane / 2 h / -70 - 20 °C

2.2: 0 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 0 °C

4.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

4.2: 0.83 h / -70 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

6.1: pyridine / 1 h / 0 °C

7.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

With pyridine; 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; tetrabutyl ammonium fluoride; palladium diacetate; boron tribromide; hydrazine hydrate; triethylamine; potassium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 2,2'-[1,2-ethanediylbis(oxy)]bisethanol; 1.1: Wolff-Kishner reduction;
DOI:10.1016/j.bmc.2011.01.017