trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

Base Information

Chemical Name:trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol
CAS No.:1032452-79-1
Molecular Formula:C₂₄H₂₄N₄O₃S
Molecular Weight:448.546
Hs Code.:

Synonyms:trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

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Technology Process of trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

There total 2 articles about trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 882562-58-5
3-(2-chloropyrimidin-4-yl)-1-(phenylsulfonyl)-1H-indole

: 27489-62-9
trans-4-hydroxycyclohexylamine

: 1032452-79-1
trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

Guidance literature:: In 1-methyl-pyrrolidin-2-one; at 120 ℃; for 3h;

Reference yield:

: 129271-98-3
1-(phenylsulfonyl)-1H-indol-3-ylboronic acid

: 1032452-79-1
trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 2 h / Heating / reflux

2: 1-methyl-pyrrolidin-2-one / 3 h / 120 °C

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; water; acetonitrile;

Reference yield: 57.0%

: 1032452-79-1
trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

: 1032452-97-3
trans-4-[4-(1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol

Guidance literature:: trans-4-[4-(1-benzenesulfonyl-1H-indol-3-yl)-pyrimidin-2-ylamino]-cyclohexanol; With sodium hydroxide; In methanol; at 20 ℃; for 6h;

With hydrogenchloride; In water;