Technology Process of methyl 3-imidazo[1,5-a]pyridin-6-yl-2,2-dimethyl-3-phenylpropanoate
There total 7 articles about methyl 3-imidazo[1,5-a]pyridin-6-yl-2,2-dimethyl-3-phenylpropanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate;
With
trichlorophosphate;
In
toluene;
at 115 ℃;
for 2.5h;
Inert atmosphere;
With
sodium carbonate; potassium carbonate;
In
water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: phenylmagnesium bromide / tetrahydrofuran
2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane
3: titanium tetrachloride / dichloromethane
4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; zinc / N,N-dimethyl acetamide / 2 h / 120 °C
5: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol / 2.5 h
6: 90 °C
7: trichlorophosphate / toluene / 115 °C
With
hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium on activated charcoal; hydrogen; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; phenylmagnesium bromide; zinc; trichlorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide; toluene;
DOI:10.1016/j.bmcl.2013.08.049
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane
2: titanium tetrachloride / dichloromethane
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; zinc / N,N-dimethyl acetamide / 2 h / 120 °C
4: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol / 2.5 h
5: 90 °C
6: trichlorophosphate / toluene / 115 °C
With
hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium on activated charcoal; hydrogen; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; zinc; trichlorophosphate;
In
methanol; dichloromethane; N,N-dimethyl acetamide; toluene;
DOI:10.1016/j.bmcl.2013.08.049
