methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

Base Information

Chemical Name:methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate
CAS No.:1025482-54-5
Molecular Formula:C₁₉H₂₂N₂O₃
Molecular Weight:326.395
Hs Code.:

Synonyms:methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

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Chemical Property of methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

Chemical Property:

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Technology Process of methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

There total 6 articles about methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 64-18-6
formic acid

: 1025482-53-4
methyl 3-(6-(aminomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

: 1025482-54-5
methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

Guidance literature:: formic acid; methyl 3-(6-(aminomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate; With potassium carbonate; at 90 ℃; Inert atmosphere;

With sodium carbonate; In water; Saturated solution;

Reference yield:

: 23100-12-1
6-chloronicotinylaldehyde

: 1025482-54-5
methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: phenylmagnesium bromide / tetrahydrofuran

2: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane

3: titanium tetrachloride / dichloromethane

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; zinc / N,N-dimethyl acetamide / 2 h / 120 °C

5: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol / 2.5 h

6: 90 °C

With hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; phenylmagnesium bromide; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2013.08.049

Reference yield:

: 80100-47-6
6-chloro-α-phenyl-3-pyridinemethanol

: 1025482-54-5
methyl 3-(6-(formamidomethyl)pyridin-3-yl)-2,2-dimethyl-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane

2: titanium tetrachloride / dichloromethane

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; zinc / N,N-dimethyl acetamide / 2 h / 120 °C

4: hydrogen; palladium on activated charcoal; hydrogenchloride / methanol / 2.5 h

5: 90 °C

With hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; hydrogen; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; zinc; In methanol; dichloromethane; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2013.08.049