[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

Base Information

Chemical Name:[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde
CAS No.:220467-07-2
Molecular Formula:C₁₈H₂₄O₂
Molecular Weight:272.387
Hs Code.:

Synonyms:[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

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Chemical Property of [(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

Chemical Property:

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Technology Process of [(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

There total 4 articles about [(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 220467-06-1
[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetonitrile

: 220467-07-2
[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

Guidance literature:: With oxonium; diisobutylaluminium hydride; In toluene; at 0 ℃; for 0.5h;
DOI:10.1016/S0040-4039(98)02535-0

Reference yield:

: 99277-05-1
(1R,2R)-2-Bromomethyl-1-(2-hydroxyethyl)-2-methyl-3-methylenecyclopentane

: 220467-07-2
[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / KN(TMS)2 / tetrahydrofuran / 0 °C

2: 93 percent / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide / 48 h / 100 °C

3: 70 percent / 1.) DIBAH; 2.) H₃O⁽¹⁺⁾ / toluene / 0.5 h / 0 °C

With oxonium; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; toluene;
DOI:10.1016/S0040-4039(98)02535-0

Reference yield:

: 104758-32-9
(1R,2R)-2-Bromomethyl-1-methoxycarbonylmethyl-2-methyl-3-methylenecyclopentane

: 220467-07-2
[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-acetaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / LiAlH₄ / diethyl ether / 1.5 h / -60 °C

2: 93 percent / KN(TMS)2 / tetrahydrofuran / 0 °C

3: 93 percent / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide / 48 h / 100 °C

4: 70 percent / 1.) DIBAH; 2.) H₃O⁽¹⁺⁾ / toluene / 0.5 h / 0 °C

With lithium aluminium tetrahydride; oxonium; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; toluene;
DOI:10.1016/S0040-4039(98)02535-0