(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester
CAS No.:442663-29-8
Molecular Formula:C₆₁H₇₂IN₃O₁₂Si
Molecular Weight:1194.25
Hs Code.:

(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(<i>tert</i>-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

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Chemical Property of (2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

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Technology Process of (2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

There total 24 articles about (2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: p-methoxyphenylisocyanide

: 75-07-0,9002-91-9
acetaldehyde

: 442663-28-7
3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-propionic acid

: 442663-24-3
2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamine

: 442663-29-8
(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: In methanol; for 1h; Heating / reflux;

Reference yield: 90.0%

: 10349-38-9
p-methoxyphenylisonitrile

: 75-07-0,9002-91-9
acetaldehyde

: 442663-28-7
3-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-2-tert-butoxycarbonylamino-propionic acid

: 442663-24-3
2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethylamine

: 442663-29-8
(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: In methanol; for 1h; Heating;
DOI:10.1021/ja026216d

Reference yield:

: 533-31-3
Sesamol

: 442663-29-8
(2-(3-benzyloxy-2-iodo-4-methoxy-5-methyl-phenyl)-1-{[2-(tert-butyl-diphenyl-silanyloxy)-1-(6-methoxymethoxy-7-methyl-benzo[1,3]dioxol-4-yl)-ethyl]-[1-(4-methoxy-phenylcarbamoyl)-ethyl]-carbamoyl}-ethyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1.1: NaH / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

1.2: 97 percent / tetrahydrofuran; dimethylformamide; various solvent(s) / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 0 - 20 °C

2.2: 92 percent / aq. H₂O₂; trimethylboronate; AcOH / tetrahydrofuran; hexane / 4.5 h / 20 °C

3.1: 89 percent / TFA / CH₂Cl₂ / 2.17 h / -10 °C

4.1: 90 percent / pyridine / CH₂Cl₂ / 0.08 h / 0 °C

5.1: 85 percent / NaBH₄ / methanol / 0.5 h / 0 °C

6.1: 91 percent / imidazole / dimethylformamide / 20 °C

7.1: 97 percent / PdCl₂(dppf) / tetrahydrofuran / 4.5 h / Heating

8.1: Pb(OAc)4 / acetonitrile / 0 °C

9.1: 436 mg / NH₂OH*HCl; NaOAc / ethanol / 1.5 h / 20 °C

10.1: 90 percent / methanol / 1 h / Heating

With pyridine; 1H-imidazole; lead(IV) acetate; sodium tetrahydroborate; n-butyllithium; hydroxylamine hydrochloride; sodium acetate; sodium hydride; trifluoroacetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 3.1: Mannich reaction / 10.1: Ugi reaction;
DOI:10.1021/ja026216d