tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

Base Information

Chemical Name:tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate
CAS No.:1356009-90-9
Molecular Formula:C₂₉H₃₁ClFN₅O₃
Molecular Weight:552.048
Hs Code.:

Synonyms:tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

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Chemical Property of tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

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Technology Process of tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

There total 12 articles about tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.7%

: 1356009-92-1
tert-butyl 2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl(2-(2-cyano-5-nitrophenoxy)ethyl)carbamate

: 1356009-90-9
tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

Guidance literature:: With iron; ammonium chloride; In methanol; water; at 65 ℃; for 2.5h;

Reference yield:

: 120-92-3
cyclopentanone

: 1356009-90-9
tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethyl ether; tetrahydrofuran / 2 h / 0 °C / Reflux

2.1: formic acid; dihydrogen peroxide / 20 - 50 °C

3.1: 3 h / 58 - 130 °C

4.1: ammonium hydroxide / 100 °C

5.1: trichlorophosphate; N,N-dimethyl-aniline / 110 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

6.2: 18 h / 75 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

8.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

With ammonium hydroxide; formic acid; dihydrogen peroxide; iron; ammonium chloride; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene;

Reference yield:

: 39835-14-8
2-hydroxy-4-nitro-benzonitrile

: 1356009-90-9
tert-butyl 2-(5-amino-2-cyanophenoxy)ethyl(2-(2-chloro-7-(4-fluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)ethyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

3.2: 18 h / 75 °C

4.1: triethylamine / dichloromethane / 1 h / 20 °C

5.1: ammonium chloride; iron / water; methanol / 2.5 h / 65 °C

With iron; ammonium chloride; caesium carbonate; triethylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;