C₂₂H₂₄N₂O₄

Base Information

• Chemical Name: C₂₂H₂₄N₂O₄
• CAS No.: 1428183-52-1
• Molecular Formula: C₂₂H₂₄N₂O₄
• Molecular Weight: 380.444
• Mol file: 1428183-52-1.mol

Synonyms:C₂₂H₂₄N₂O₄

Chemical Property of C₂₂H₂₄N₂O₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₄N₂O₄

There total 6 articles about C₂₂H₂₄N₂O₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate (65713-63-5) + 1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carboxaldehyde (347331-30-0) → C22H24N2O4 (1428183-52-1)

Guidance literature:

With potassium hydrogensulfate; In ethanol; at 70 - 80 ℃; for 3h;

DOI:10.1021/jm400009c

Reference yield:

2,5-hexanedione (110-13-4) → C22H24N2O4 (1428183-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation

2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 100 °C / Inert atmosphere

3.1: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C

With potassium hydrogensulfate; silica gel; toluene-4-sulfonic acid; trichlorophosphate; In ethanol; 1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;

DOI:10.1021/jm400009c

Reference yield:

4-methoxy-aniline (104-94-9) → C22H24N2O4 (1428183-52-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; silica gel / neat (no solvent) / 180 °C / Microwave irradiation

2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere

2.2: 3 h / 100 °C / Inert atmosphere

3.1: potassium hydrogensulfate / ethanol / 3 h / 70 - 80 °C

With potassium hydrogensulfate; silica gel; toluene-4-sulfonic acid; trichlorophosphate; In ethanol; 1.1: |Paal-Knorr Pyrrole Synthesis / 2.2: |Vilsmeier-Haack Formylation;

DOI:10.1021/jm400009c

upstream raw materials:

ethyl 5-methyl-3-oxo-1,2-dihydropyrrole-4-carboxylate

1-(4-methoxyphenyl)-2,5-dimethyl-1H-pyrrole-3-carboxaldehyde

2,5-hexanedione

4-methoxy-aniline