3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

Base Information

Chemical Name:3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile
CAS No.:1394838-73-3
Molecular Formula:C₁₅H₁₈F₂N₂O₂S
Molecular Weight:328.383
Hs Code.:

Synonyms:3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

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Chemical Property of 3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

Chemical Property:

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Technology Process of 3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

There total 5 articles about 3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394838-70-0
3-((2R,4R)-1-(tert-butylsulfonyl)-4-hydroxypyrrolidin-2-yl)-5-fluorobenzonitrile

: 1394838-73-3
3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

Guidance literature:: With triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; In dichloromethane; at -50 - 0 ℃; for 2.16667h;

Reference yield:

: 1003708-42-6
3-fluoro-5-formylbenzonitrile

: 1394838-73-3
3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: titanium(IV) tetraethanolate / tetrahydrofuran / 23 h / 9 - 20 °C

2.1: zinc; water / N,N,N,N,N,N-hexamethylphosphoric triamide / 3.75 h / 18 - 28 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22.3 h / 0 - 20 °C

4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 17 h / 20 - 86.6 °C

4.2: 20 °C

5.1: triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 2.17 h / -50 - 0 °C

With titanium(IV) tetraethanolate; water; potassium carbonate; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; potassium iodide; zinc; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1394838-58-4
(R,E)-N-(3-cyano-5-fluorobenzylidene)-2-methylpropane-2-sulfinamide

: 1394838-73-3
3-((2R,4S)-1-(tert-butylsulfonyl)-4-fluoropyrrolidin-2-yl)-5-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; water / N,N,N,N,N,N-hexamethylphosphoric triamide / 3.75 h / 18 - 28 °C

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 22.3 h / 0 - 20 °C

3.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 17 h / 20 - 86.6 °C

3.2: 20 °C

4.1: triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 2.17 h / -50 - 0 °C

With water; potassium carbonate; triethylamine tris(hydrogen fluoride); 3-chloro-benzenecarboperoxoic acid; ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; potassium iodide; zinc; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; N,N-dimethyl-formamide;