5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

Base Information

Chemical Name:5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide
CAS No.:1394838-11-9
Molecular Formula:C₁₉H₁₅F₂N₅O
Molecular Weight:367.358
Hs Code.:

Synonyms:5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

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Chemical Property of 5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

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Technology Process of 5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

There total 20 articles about 5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1394839-49-6
5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)-N,N-bis(4-methoxybenzyl)pyrazolo[1,5-a]pyridine-3-carboxamide

: 1394838-11-9
5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 50 ℃; for 12h; Product distribution / selectivity;

Reference yield:

: 1364890-33-4
(2R,4S)-tert-butyl 2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidine-1-carboxylate

: 1394838-11-9
5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave

3: trifluoroacetic acid / dichloromethane / 12 h / 50 °C

With caesium carbonate; trifluoroacetic acid; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane;

Reference yield:

: N-((1R)-1-(3-cyano-5-fluorophenyl)-2-(oxiran-2-yl)ethyl)-2-methylpropane-2-sulfonamide

: 1394838-11-9
5-((2R,4S)-2-(3-cyano-5-fluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 17 h / 20 - 86.6 °C

1.2: 20 °C

2.1: triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate / dichloromethane / 2.17 h / -50 - 0 °C

3.1: methoxybenzene; trifluorormethanesulfonic acid / dichloromethane / 0.58 h / -30 - -2 °C

3.2: 0.5 h / -10 - 3 °C

4.1: caesium carbonate / palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave

5.1: trifluoroacetic acid / dichloromethane / 12 h / 50 °C

With trifluorormethanesulfonic acid; potassium carbonate; caesium carbonate; methoxybenzene; triethylamine tris(hydrogen fluoride); ethanaminium,N-(difluoro-λ⁴-sulfanylidene)-N-ethyl-,tetrafluoroborate; trifluoroacetic acid; potassium iodide; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;