{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

Base Information

Chemical Name:{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester
CAS No.:149741-61-7
Molecular Formula:C₂₃H₂₃Cl₂N₂O₇P
Molecular Weight:541.325
Hs Code.:

Synonyms:{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

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Chemical Property of {2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

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Technology Process of {2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

There total 3 articles about {2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 149741-60-6
{(E)-2-[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-vinyl}-phosphonic acid bis-(2-chloro-phenyl) ester

: 149741-61-7
{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

Guidance literature:: With hydrogen; acetic acid; palladium; In methanol;
DOI:10.1016/S0040-4039(00)73545-3

Reference yield:

: 105972-87-0
di(2-chlorophenyl) chloromethylphosphonate

: 149741-61-7
{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

Guidance literature:: Multi-step reaction with 4 steps

3: 83 percent

4: 97 percent / H₂, AcOH / Pd / methanol

With hydrogen; acetic acid; palladium; In methanol;
DOI:10.1016/S0040-4039(00)73545-3

Reference yield:

: 3'-O-(tert-butyldimethylsilyl)-5'-deoxy-5'5'-(N,N'-diphenylethylenediamino)thymidine

: 149741-61-7
{2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / p-toluenesulfonic acid

2: 83 percent

3: 97 percent / H₂, AcOH / Pd / methanol

With hydrogen; toluene-4-sulfonic acid; acetic acid; palladium; In methanol;
DOI:10.1016/S0040-4039(00)73545-3