105972-87-0

Upstream product

• 95-57-8 2-monochlorophenol 
• 1983-26-2 chloromethylphosphonic dichloride 

Downstream Products

• 149741-62-8 {2-[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester 
• 149741-61-7 {2-[(2R,3S,5R)-3-Hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-ethyl}-phosphonic acid bis-(2-chloro-phenyl) ester 
• 149741-59-3 Bis(o-chlorophenyl) (triphenylphosphoranylidenemethyl)phosphonate 
• 182810-28-2 C₄₈H₄₈ClN₄O₁₃P 
• 182810-26-0 C₂₇H₃₀ClN₄O₁₁P 
• 149741-60-6 {(E)-2-[(2R,3S,5R)-3-(tert-Butyl-dimethyl-silanyloxy)-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-yl]-vinyl}-phosphonic acid bis-(2-chloro-phenyl) ester 

Relevant academic research and scientific papers

Synthesis and preliminary biochemical studies with 5'-deoxy-5'-methylidyne phosphonate linked thymidine oligonucleotides

Thymidine deoxyoligonucleotides having a 5'-deoxy-5'-methylidyne phosphonate internucleotide linkage were synthesized. Relative to natural DNA, these oligomers were nuclease resistant and formed duplexes with reduced stability.