(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester
CAS No.:783362-54-9
Molecular Formula:C₄₂H₅₅N₅O₁₀
Molecular Weight:789.926
Hs Code.:

(5-acetylamino-5-{4-[(2-{2-[2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid <i>tert</i>-butyl ester

Synonyms:(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

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Chemical Property of (5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

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Technology Process of (5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

There total 10 articles about (5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104-03-0
4-nitrobenzeneacetic acid

: 783362-54-9
(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 93 percent / SOCl₂ / 24 h / 20 °C

2: 85 percent / NBS / CCl₄ / 5 h / Irradiation

3: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

4: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

5: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

6: 84 percent / HATU; collidine / dimethylformamide / 12 h

7: piperidine; TFA / dimethylformamide / 0.5 h

8: DIEA / CH₂Cl₂ / 1 h

9: aq. LiOH / methanol / 2 h / 20 °C

10: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; thionyl chloride; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 2945-08-6
methyl (4-nitrophenyl)acetate

: 783362-54-9
(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 85 percent / NBS / CCl₄ / 5 h / Irradiation

2: 73.2 percent / dimethylformamide; H₂O / 12 h / 100 °C

3: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

4: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

5: 84 percent / HATU; collidine / dimethylformamide / 12 h

6: piperidine; TFA / dimethylformamide / 0.5 h

7: DIEA / CH₂Cl₂ / 1 h

8: aq. LiOH / methanol / 2 h / 20 °C

9: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; N-Bromosuccinimide; tetrafluoroboric acid; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1039/b404471a

Reference yield:

: 29704-42-5
4-nitromandelic acid methyl ester acetate

: 783362-54-9
(5-acetylamino-5-{4-[(2-{2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethoxy]-ethoxy}-ethylcarbamoyl)-hydroxy-methyl]-phenylcarbamoyl}-pentyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / aq. HBF₄ / methanol / 24 h / 20 °C

2: 92.7 percent / H₂ / Pd/C / methanol / 8 h / 20 °C

3: 84 percent / HATU; collidine / dimethylformamide / 12 h

4: piperidine; TFA / dimethylformamide / 0.5 h

5: DIEA / CH₂Cl₂ / 1 h

6: aq. LiOH / methanol / 2 h / 20 °C

7: HOBt; EDC / dimethylformamide / 8.5 h / 0 - 20 °C

With piperidine; 2,3,5-trimethyl-pyridine; lithium hydroxide; tetrafluoroboric acid; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b404471a