7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Base Information

• Chemical Name: 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS No.: 118298-16-1
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• ChEMBL ID: CHEMBL422274
• DSSTox Substance ID: DTXSID10469346,DTXSID301312417
• Nikkaji Number: J780.849F
• Mol file: 118298-16-1.mol

Synonyms:4003-89-8;7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine;7-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-ylamine;118298-16-1;2-AMINO-1,2,3,4-TETRAHYDRO-7-METHOXYNAPHTHALENE;2-AMINO-7-METHOXYTETRALIN;CHEMBL422274;7-methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine;7-methoxytetralin-2-amine;7-methoxy-2-aminotetralin;7-methoxy-2-aminotetraline;7-methoxy-2-amino-tetralin;SCHEMBL267102;DTXSID10469346;ZNWNWWLWFCCREO-UHFFFAOYSA-N;DTXSID301312417;BDBM50020509;MFCD06739168;AKOS015964896;AB06762;AB06766;AB28763;DS-18040;PD033605;3-Amino-2-(4-methylphenylamino)benzoicacid;FT-0635099;FT-0659611;FT-0694800;A12493;EN300-256674;2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene;7-methoxy-1,2,3,4-tetrahydronapthalen-2-ylamine;J-519285;(S)-7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-ylamine;7-Methoxy-1 pound not2 pound not3 pound not4-tetrahydronaphthalen-2-amine

Chemical Property of 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

Chemical Property:

• PSA: 35.25000
• LogP: 2.21150
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 177.115364102
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(CCC(C2)N)C=C1

Technology Process of 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

There total 35 articles about 7-Methoxy-1,2,3,4-tetrahydronaphthalen-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

7-methoxy-2-(trifluoroacetylamino)-1,2,3,4-tetrahydronaphthalene (1262722-83-7) → 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1)

Guidance literature:

With water; potassium carbonate; In methanol; at 20 ℃; for 22.5h; Inert atmosphere;

DOI:10.1016/j.tet.2010.11.010

Reference yield: 92.0%

7-Methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthaleneamine hydrochloride (3880-78-2,158223-16-6) → 2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1)

Guidance literature:

With sodium hydroxide; In water; ethyl acetate;

DOI:10.1021/jm101479y

Reference yield: 90.0%

N-[(2S)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-yl]benzamide (231623-76-0) → (2S)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (121216-42-0,118298-16-1)

Guidance literature:

With methanesulfonic acid; acetic acid; at 160 ℃; for 24h;

DOI:10.1016/S0040-4039(99)00807-2

upstream raw materials:

2-amino-7-methoxynaphthalene

7-methoxy-3,4-dihydro-1H-naphthalen-2-one oxime

(1,2,3,4-tetrahydro-7-methoxy-2-naphthyl)hydrazine

benzyl (3aRS,9bSR)-N-(2,3,3a,4,5,9b-hexahydro-8-methoxy-2-oxonaphth<2.1-d>oxazol-3-yl)carbamate

Downstream raw materials:

7-hydroxy-1,2,3,4-tetrahydro-2-naphthylamine hydrobromide

(2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

(2S)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

7-OH-AT