(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

Base Information

Chemical Name:(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate
CAS No.:639467-37-1
Molecular Formula:C₁₈H₁₅ClN₄O₂
Molecular Weight:354.796
Hs Code.:

Synonyms:(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

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Chemical Property of (1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

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Technology Process of (1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

There total 6 articles about (1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 65-85-0,8013-63-6
benzoic acid

: 639467-36-0
(1'R,4'R)-1'-methyl-1'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-4'-ol

: 639467-37-1
(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo030238g

Reference yield:

: 61305-35-9
(R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enone

: 639467-37-1
(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / diethyl ether / 3 h / -40 °C

2: 30 percent / Ph₃P; diisopropylazodicarboxylate / tetrahydrofuran / 24 h / 20 °C

3: 71 percent / K-10 clay / ethyl acetate; methanol; H₂O / 8 h / 75 °C

4: 67 percent / Ph₃P; diisopropylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With di-isopropyl azodicarboxylate; K-10 clay; triphenylphosphine; In tetrahydrofuran; methanol; diethyl ether; water; ethyl acetate; 2: Mitsunobu reaction / 4: Mitsunobu reaction;
DOI:10.1021/jo030238g

Reference yield:

: 104069-09-2
(1S,4R)-4-((tert-butyldimethylsilyl)oxy)cyclopent-2-enol

: 639467-37-1
(1'S,4'R)-4'-methyl-4'-(6-chloro-9H-purin-9-yl)-2'-cyclopenten-1-yl benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 84.13 percent / pyridinium chlorochromate / CH₂Cl₂ / 14 h

2: 60 percent / diethyl ether / 3 h / -40 °C

3: 30 percent / Ph₃P; diisopropylazodicarboxylate / tetrahydrofuran / 24 h / 20 °C

4: 71 percent / K-10 clay / ethyl acetate; methanol; H₂O / 8 h / 75 °C

5: 67 percent / Ph₃P; diisopropylazodicarboxylate / tetrahydrofuran / 2 h / 20 °C

With di-isopropyl azodicarboxylate; K-10 clay; triphenylphosphine; pyridinium chlorochromate; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; 3: Mitsunobu reaction / 5: Mitsunobu reaction;
DOI:10.1021/jo030238g