3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

Base Information

Chemical Name:3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester
CAS No.:940877-13-4
Molecular Formula:C₁₈H₂₃ClO₂
Molecular Weight:306.832
Hs Code.:

Synonyms:3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

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Technology Process of 3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

There total 2 articles about 3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 850534-46-2
(3R)-5-(chloromethyl)-1-phenylhex-5-en-3-ol

: 3350-78-5
3,3-Dimethylacryloyl chloride

: 940877-13-4
3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 36h;
DOI:10.1021/ol070573h

Reference yield:

: 104-53-0
3-phenyl-propionaldehyde

: 940877-13-4
3-methyl-but-2-enoic acid (R)-3-chloromethyl-1-phenethyl-but-3-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / (S)-BINOL; 4 Angstroem molecular sieves; CF₃CO₂H / titanium(IV) isopropoxide / CH₂Cl₂ / 72.5 h / -78 - -20 °C

2: 76 percent / pyridine; DMAP / CH₂Cl₂ / 36 h / 0 °C

With pyridine; dmap; 4 A molecular sieve; (S)-[1,1']-binaphthalenyl-2,2'-diol; trifluoroacetic acid; titanium(IV) isopropylate; In dichloromethane;
DOI:10.1021/ol070573h