Technology Process of 1,2,3,10b-tetrahydro-5,6,8,9-tetramethoxy-1-benzylindeno<1,2,3-ij>isoquinoline
There total 10 articles about 1,2,3,10b-tetrahydro-5,6,8,9-tetramethoxy-1-benzylindeno<1,2,3-ij>isoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
for 2.5h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: SOCl2 / 24 h / Ambient temperature
2: CH2Cl2 / 1 h / 0 °C
3: 93 percent / SOCl2
4: 92 percent / tetrahydrofuran / 1.) reflux, 10 min, 2.) room temperature, 20 h
5: 44 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / -10 - -5 °C
6: 79 percent / 3M HCl / H2O / 0.33 h / Heating
7: 88 percent / benzylamine / 24 h / 120 - 125 °C
8: 97 percent / pyridine
9: 71 percent / NaH / tetrahydrofuran / Heating
10: 92 percent / POCl3 / toluene / 4 h / Heating
11: 74 percent / NaBH4 / ethanol / 2.5 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium hydride; benzylamine; trichlorophosphate;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 92 percent / tetrahydrofuran / 1.) reflux, 10 min, 2.) room temperature, 20 h
2: 44 percent / n-BuLi / hexane; tetrahydrofuran / 3 h / -10 - -5 °C
3: 79 percent / 3M HCl / H2O / 0.33 h / Heating
4: 88 percent / benzylamine / 24 h / 120 - 125 °C
5: 97 percent / pyridine
6: 71 percent / NaH / tetrahydrofuran / Heating
7: 92 percent / POCl3 / toluene / 4 h / Heating
8: 74 percent / NaBH4 / ethanol / 2.5 h / Ambient temperature
With
pyridine; hydrogenchloride; sodium tetrahydroborate; n-butyllithium; sodium hydride; benzylamine; trichlorophosphate;
In
tetrahydrofuran; ethanol; hexane; water; toluene;
