4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol

Base Information

• Chemical Name: 4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol
• CAS No.: 1288996-84-8
• Molecular Formula: C₂₅H₃₃NO₅Si
• Molecular Weight: 455.626

Synonyms:4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol

Chemical Property of 4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol

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Technology Process of 4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol

There total 1 articles about 4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

(R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran (1202784-98-2) + 4-hydroxy-3-nitrobenzenediazonium tetrafluoroborate (1252036-52-4) → 4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol (1288996-84-8)

Guidance literature:

With sodium acetate; palladium diacetate; In acetonitrile; at 20 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/jo2002787

Reference yield: 99.0%

4-((2S,6R)-6-(4-(tert-butyldimethylsilyloxy)phenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol (1288996-84-8) → 4-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol (1288996-91-7)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo2002787

upstream raw materials:

(R)-2-[4-(tert-butyldimethylsilyloxy)phenethyl]-3,4-dihydro-2H-pyran

4-hydroxy-3-nitrobenzenediazonium tetrafluoroborate

Downstream raw materials:

4-((2S,6R)-6-(4-hydroxyphenylethyl)-5,6-dihydro-2H-pyran-2-yl)-2-nitrophenol

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