ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Name:ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
CAS No.:1374342-31-0
Molecular Formula:C₁₉H₁₄F₅N₃O₃
Molecular Weight:427.33
Hs Code.:

Synonyms:ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Chemical Property of ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

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Technology Process of ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

There total 4 articles about ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374342-30-9
ethyl 1-{6-[5-(difluoromethyl)-2-methoxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374342-31-0
ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: With trimethylsilyl iodide; In dichloromethane; at 80 ℃; for 2h;

Reference yield:

: 1374342-29-6
ethyl 1-[6-(5-formyl-2-methoxyphenyl)pyridin-2-yl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

: 1374342-31-0
ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 114 h / 20 °C

2: trimethylsilyl iodide / dichloromethane / 2 h / 80 °C

With trimethylsilyl iodide; diethylamino-sulfur trifluoride; In dichloromethane;

Reference yield:

: 571-55-1
ethyl 2-(ethoxymethylidene)-4,4,4-trifluoro-3-oxobutanoate

: 1374342-31-0
ethyl 1-{6-[5-(difluoromethyl)-2-hydroxyphenyl]pyridin-2-yl}-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetonitrile / 0.83 h / 60 °C

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / acetonitrile; water / 18 h / 80 °C / Inert atmosphere

3: diethylamino-sulfur trifluoride / dichloromethane / 114 h / 20 °C

4: trimethylsilyl iodide / dichloromethane / 2 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; trimethylsilyl iodide; diethylamino-sulfur trifluoride; sodium carbonate; triethylamine; In dichloromethane; water; acetonitrile;