6-FLUORO-3-METHYLBENZODISOXAZOLE

Base Information

• Chemical Name: 6-FLUORO-3-METHYLBENZODISOXAZOLE
• CAS No.: 117933-03-6
• Molecular Formula: C8H6 F N O
• Molecular Weight: 151.14
• Hs Code.: 2934999090
• Mol file: 117933-03-6.mol

Synonyms:6-Fluoro-3-methylbenzisoxazole

Chemical Property of 6-FLUORO-3-METHYLBENZODISOXAZOLE

Chemical Property:

• Vapor Pressure: 0.082mmHg at 25°C
• Refractive Index: 1.569
• Boiling Point: 234.1°Cat760mmHg
• Flash Point: 95.4°C
• PSA: 26.03000
• Density: 1.258g/cm³
• LogP: 2.27530

Purity/Quality:

98%min ^*data from raw suppliers

6-Fluoro-3-methyl-benzo[d]isoxazole ＞97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-FLUORO-3-METHYLBENZODISOXAZOLE

There total 7 articles about 6-FLUORO-3-METHYLBENZODISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-(4-fluoro-2-hydroxyphenyl)ethan-1-one oxime (221559-20-2) → 6-fluoro-3-methyl-1,2-benzisoxazole (117933-03-6)

Guidance literature:

With sodium acetate; acetic anhydride; In N,N-dimethyl-formamide; for 3 - 4h; Heating / reflux;

Reference yield:

(E)-1-(4-fluoro-2-hydroxyphenyl)ethan-1-one oxime → 6-fluoro-3-methyl-1,2-benzisoxazole (117933-03-6)

Guidance literature:

With sodium acetate; acetic anhydride; In N,N-dimethyl-formamide; for 4h; Heating / reflux;

Reference yield:

4-Fluoro-2-hydroxyacetophenone (1481-27-2) + 1,1'-carbonyldiimidazole (530-62-1) → 6-fluoro-3-methyl-1,2-benzisoxazole (117933-03-6)

Guidance literature:

With triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1-(4-fluoro-2-hydroxyphenyl)ethan-1-one oxime

4-Fluoro-2-hydroxyacetophenone

1,1'-carbonyldiimidazole

5-fluoro-2-(1-iminoethyl)phenol

Downstream raw materials:

6-butyl-3-[(6-fluoro-1.2-benzisoxazol-3-yl)methyl]-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}pyrimidin-4(3H)-one

benzyl 1-(4-fluoro-2-hydroxyphenyl)-1-ethylcarbamate

6-amino-3-methyl-1,2-benzisoxazole

Refernces

• 1、 -. "5-6-5 azatricyclic compound and preparation method thereof". Paragraph 0033; 0043-0045. . Retrieved 2019/10/01.
• 2、 -. "ISOXAZOLINE DERIVATIVES AND THEIR USES IN AGRICULTURE RELATED APPLICATION". Paragraph 00210. . Retrieved 2019/04/26.