4'-Fluoro-2'-hydroxyacetophenone

Base Information

• Chemical Name: 4'-Fluoro-2'-hydroxyacetophenone
• CAS No.: 1481-27-2
• Molecular Formula: C8H7FO2
• Molecular Weight: 154.141
• Hs Code.: 29147000
• DSSTox Substance ID: DTXSID30371992
• Nikkaji Number: J1.026.010H
• Wikidata: Q72479892
• Mol file: 1481-27-2.mol

Synonyms:4'-Fluoro-2'-hydroxyacetophenone;1481-27-2;1-(4-fluoro-2-hydroxyphenyl)ethanone;4-Fluoro-2-hydroxyacetophenone;1-(4-fluoro-2-hydroxyphenyl)ethan-1-one;Ethanone, 1-(4-fluoro-2-hydroxyphenyl)-;MFCD00143203;4/'-Fluoro-2/'-hydroxyacetophenone;1-(2-Hydroxy-4-fluorophenyl)ethanone;1-[2-hydroxy-4-fluorophenyl]ethanone;1-(4-fluoro-2-hydroxy-phenyl)ethanone;2-acetyl-5-fluorophenol;SCHEMBL537488;4'-fluoro-2'hydroxyacetophenone;DTXSID30371992;2'-Hydroxy-4'-fluoroacetophenone;4'-Flouro-2'-hydroxyacetophenone;HLTBTUXAMVOKIH-UHFFFAOYSA-N;AM758;BCP27027;CL8668;AKOS005207270;AC-5482;CS-W018050;FS-1050;1-(4-fluoro-2-hydroxyphenyl)-ethanone;(2-hydroxy-4-fluoro phenyl)-1-ethanone;1-(4-fluoro-2-hydroxy-phenyl)-ethanone;4'-Fluoro-2'-hydroxyacetophenone, 98%;2'-Hydroxy-4'-fluorophenyl methyl ketone;SY048694;F0723;FT-0602135;EN300-67539;J-008443;F0001-0527;Z1080542132;4 inverted exclamation mark -Fluoro-2 inverted exclamation mark -hydroxyacetophenone;InChI=1/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H

Chemical Property of 4'-Fluoro-2'-hydroxyacetophenone

Chemical Property:

• Appearance/Colour: power
• Vapor Pressure: 0.0525mmHg at 25°C
• Melting Point: 32-34 °C
• Refractive Index: 1.559
• Boiling Point: 237.5 °C at 760 mmHg
• PKA: 9.17±0.10(Predicted)
• Flash Point: 97.434 °C
• PSA: 37.30000
• Density: 1.247 g/cm³
• LogP: 1.73390
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 154.04300762
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

4''-Fluoro-2''-hydroxyacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)C1=C(C=C(C=C1)F)O
• Uses: 4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

Technology Process of 4'-Fluoro-2'-hydroxyacetophenone

There total 8 articles about 4'-Fluoro-2'-hydroxyacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-fluorophenyl acetate (701-83-7) → 4-Fluoro-2-hydroxyacetophenone (1481-27-2)

Guidance literature:

With aluminium trichloride; at 160 ℃; for 2h;

DOI:10.1021/jm00388a012

Reference yield: 79.0%

2',4'-difluoroacetophenone (364-83-0) → 4-Fluoro-2-hydroxyacetophenone (1481-27-2) + 1-(2-fluoro-4-hydroxyphenyl)ethanone (98619-07-9)

Guidance literature:

2',4'-difluoroacetophenone; With sodium hydroxide; calcium hydroxide; In water; for 18h; Reflux;

With hydrogenchloride; In water;

DOI:10.1080/00304940903163723

Reference yield: 70.0%

3-fluorophenol (372-20-3) + acetyl chloride (75-36-5) → 4-Fluoro-2-hydroxyacetophenone (1481-27-2)

Guidance literature:

With aluminum (III) chloride; at 130 ℃; for 2h;

upstream raw materials:

3-fluorophenyl acetate

3-fluorophenol

acetic acid

2',4'-difluoroacetophenone

Downstream raw materials:

4-fluoro-2-(4-pyridinylmethoxy)acetophenone

1-(4-fluoro-2-methoxy-phenyl)-ethanone

3-(2,6-difluorophenyl)-1-(4-fluoro-2-hydroxyphenyl)-2-propen-1-one

1-(4-fluoro-2-hydroxyphenyl)ethan-1-one oxime