3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide

Base Information

• Chemical Name: 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide
• CAS No.: 866772-51-2
• Molecular Formula: C₂₆H₃₃N₅O₄S₂
• Molecular Weight: 543.711

Synonyms:3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide

Chemical Property of 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide

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Technology Process of 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide

There total 1 articles about 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-methoxythiazolo[5,4-b]pyridin-2-amine (13797-77-8) + 3-cyclopentyl-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionic acid (866774-36-9) → 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide (866772-51-2)

Guidance literature:

3-cyclopentyl-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionic acid; With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 5h;

5-methoxythiazolo[5,4-b]pyridin-2-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 28 ℃; for 75.5h;

DOI:10.1021/jm900839k

Reference yield:

3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide (866772-51-2) → 3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)-phenyl]-propionamide dihydrochloride

Guidance literature:

With hydrogenchloride; In isopropyl alcohol; at 0 - 20 ℃; for 3h;

Reference yield:

3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide (866772-51-2) → (R)-3-cyclopentyl-N-(5-methoxy-thiazolo[5,4-b]pyridin-2-yl)-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionamide hydrochloride

Guidance literature:

With chiralcel HPLC column; Resolution of racemate;

DOI:10.1021/jm900839k

upstream raw materials:

5-methoxythiazolo[5,4-b]pyridin-2-amine

3-cyclopentyl-2-[4-(4-methyl-piperazine-1-sulfonyl)phenyl]propionic acid

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