tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

Base Information

Chemical Name:tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate
CAS No.:1439908-38-9
Molecular Formula:C₁₆H₂₀ClF₂N₅O₂
Molecular Weight:387.817
Hs Code.:

Synonyms:tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

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Chemical Property of tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

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Technology Process of tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

There total 7 articles about tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374973-19-9
tert-butyl (1S,2S)-2-amino-3,3-difluorocyclohexylcarbamate

: 3177-24-0
2,4-dichloropyrimidine-5-carbonitrile

: 1439908-36-7
tert-butyl (1S,2S)-2-(4-chloro-5-cyanopyrimidin-2-ylamino)-3,3-difluorocyclohexylcarbamate

: 1439908-38-9
tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 100 ℃; for 0.333333h;

Reference yield:

: 1374973-15-5
tert-butyl (1S,2R)-3,3-difluoro-2-hydroxycyclohexylcarbamate

: 1439908-36-7
tert-butyl (1S,2S)-2-(4-chloro-5-cyanopyrimidin-2-ylamino)-3,3-difluorocyclohexylcarbamate

: 1439908-38-9
tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 0.17 h / Cooling with ice

2: sodium azide / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate

4: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 100 °C

With pyridine; sodium azide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; ethyl acetate;

Reference yield:

: 1374973-16-6
(1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

: 1439908-36-7
tert-butyl (1S,2S)-2-(4-chloro-5-cyanopyrimidin-2-ylamino)-3,3-difluorocyclohexylcarbamate

: 1439908-38-9
tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / 1-methyl-pyrrolidin-2-one / 3 h / 100 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate

3: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 0.33 h / 100 °C

With sodium azide; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; ethyl acetate;