(1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

Base Information

• Chemical Name: (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate
• CAS No.: 1374973-16-6
• Molecular Formula: C₁₂H₁₈F₅NO₅S
• Molecular Weight: 383.337
• Mol file: 1374973-16-6.mol

Synonyms:(1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

Chemical Property of (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate

There total 6 articles about (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trifluoromethylsulfonic anhydride (358-23-6) + tert-butyl (1S,2R)-3,3-difluoro-2-hydroxycyclohexylcarbamate (1374973-15-5) → (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate (1374973-16-6)

Guidance literature:

With pyridine; In dichloromethane; for 0.166667h; Cooling with ice;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate (1374973-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran

2: pyridine / dichloromethane / 0.17 h / Cooling with ice

With pyridine; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

(1R,6S)-6-amino-2,2-difluorocyclohexanol (1374973-14-4) → (1R,6S)-6-(tert-butoxycarbonylamino)-2,2-difluorocyclohexyl trifluoromethanesulfonate (1374973-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran

2: pyridine / dichloromethane / 0.17 h / Cooling with ice

With pyridine; triethylamine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

trifluoromethylsulfonic anhydride

tert-butyl (1S,2R)-3,3-difluoro-2-hydroxycyclohexylcarbamate

di-tert-butyl dicarbonate

(1R,6S)-6-amino-2,2-difluorocyclohexanol

Downstream raw materials:

tert-butyl (1S,2S)-2-(4-chloro-5-cyanopyrimidin-2-ylamino)-3,3-difluorocyclohexylcarbamate

tert-butyl (1S,2S)-2-(2-chloro-5-cyanopyrimidin-4-ylamino)-3,3-difluorocyclohexylcarbamate

tert-butyl (1S,2S)-2-(4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-5-cyanopyrimidin-2-ylamino)-3,3-difluorocyclohexylcarbamate

4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-((1S,6S)-6-amino-2,2-difluorocyclohexylamino)pyrimidin-5-carboxamide