4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne

Base Information

• Chemical Name: 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne
• CAS No.: 204578-52-9
• Molecular Formula: C₂₈H₃₈O₅
• Molecular Weight: 454.607

Synonyms:4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne

Chemical Property of 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne

Chemical Property:

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Technology Process of 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne

There total 2 articles about 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(4-tert-Butyl-phenyl)-1,7-bis-(tetrahydro-pyran-2-yloxy)-hepta-2,5-diyn-4-ol (204578-51-8) + methyl iodide (74-88-4) → 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne (204578-52-9)

Guidance literature:

With sodium hydride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(98)00011-8

Reference yield:

p-tert-butyl benzoyl chloride (1710-98-1) → 4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne (204578-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) EtMgBr / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 2 h

2: 70 percent / NaH / tetrahydrofuran / 0.5 h / Ambient temperature

With ethylmagnesium bromide; sodium hydride; In tetrahydrofuran;

DOI:10.1016/S0040-4020(98)00011-8

Reference yield: 63.0%

4-(tert-butylphenyl)-4-methoxy-1,7-(tetrahydropyranyloxy)-2,5-heptadiyne (204578-52-9) → 4-(4-tert-Butyl-phenyl)-4-methoxy-hepta-2,5-diyne-1,7-diol (204578-53-0)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; at 55 ℃; for 2h;

DOI:10.1016/S0040-4020(98)00011-8

upstream raw materials:

4-(4-tert-Butyl-phenyl)-1,7-bis-(tetrahydro-pyran-2-yloxy)-hepta-2,5-diyn-4-ol

methyl iodide

p-tert-butyl benzoyl chloride

Downstream raw materials:

4-(4-tert-Butyl-phenyl)-4-methoxy-hepta-2,5-diyne-1,7-diol

4-(4-tert-Butyl-phenyl)-4-methoxy-hepta-2,5-diynedial

4,10,16-Tris-(4-tert-butyl-phenyl)-4,10,16-trimethoxy-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7,13-triol

4,10,16-Tris-(4-tert-butyl-phenyl)-4,10,16-trimethoxy-13-(tetrahydro-pyran-2-yloxy)-cyclooctadeca-2,5,8,11,14,17-hexayne-1,7-diol

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