3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

Base Information

Chemical Name:3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid
CAS No.:135892-98-7
Molecular Formula:C₂₉H₃₂O₅Si
Molecular Weight:488.656
Hs Code.:

Synonyms:3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

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Chemical Property of 3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

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Technology Process of 3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

There total 7 articles about 3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 4861-79-4
magnesium methyl carbonate

: 135932-60-4
1-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-ethanone

: 135892-98-7
3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

Guidance literature:: In N,N-dimethyl-formamide; at 125 ℃; for 1.83333h;
DOI:10.1021/jo960330v

Reference yield:

: 132-64-9,214827-48-2
dibenzofuran

: 135892-98-7
3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 82.5 percent / Br₂ / acetic acid / Ambient temperature

2: 71 percent / AlCl₃ / CS₂

3: 97 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / Heating

4: 99 percent / imidazole / dimethylformamide / 20 h

5: 1.) EtMgBr, Mg / 1.) THF, 65 deg C, 90 min, 2.) THF, room temperature, 20 h

6: 93 percent / PCC, Al₂O₃ / CH₂Cl₂

7: 78 percent / dimethylformamide / 1.83 h / 125 °C

With 1H-imidazole; aluminum oxide; sodium tetrahydroborate; aluminium trichloride; ethylmagnesium bromide; bromine; magnesium; pyridinium chlorochromate; In carbon disulfide; dichloromethane; water; acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo960330v

Reference yield:

: 86-76-0
2-bromodibenzo[b,d]furan

: 135892-98-7
3-{8-[1-(tert-Butyl-dimethyl-silanyloxy)-2-phenyl-ethyl]-dibenzofuran-2-yl}-3-oxo-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / AlCl₃ / CS₂

2: 97 percent / NaBH₄ / propan-2-ol; H₂O / 1 h / Heating

3: 99 percent / imidazole / dimethylformamide / 20 h

4: 1.) EtMgBr, Mg / 1.) THF, 65 deg C, 90 min, 2.) THF, room temperature, 20 h

5: 93 percent / PCC, Al₂O₃ / CH₂Cl₂

6: 78 percent / dimethylformamide / 1.83 h / 125 °C

With 1H-imidazole; aluminum oxide; sodium tetrahydroborate; aluminium trichloride; ethylmagnesium bromide; magnesium; pyridinium chlorochromate; In carbon disulfide; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jo960330v