Technology Process of methyl 1-(but-3-enyl)-3-cyclohexyl-2-phenyl-7-vinyl-1H-indole-6-carboxylate
There total 8 articles about methyl 1-(but-3-enyl)-3-cyclohexyl-2-phenyl-7-vinyl-1H-indole-6-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-cyclohexyl-7-ethenyl-2-phenyl-1H-indole-6-carboxylic acid, methyl ester;
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.0833333h;
1-bromo-4-butene;
In
N,N-dimethyl-formamide;
for 25.5h;
With
hydrogenchloride; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium methylate / methanol / 23 h / 20 - 60 °C / Heating / reflux
1.2: 20 °C
2.1: hydrogen / 20% Pd(OH)2 on carbon / tetrahydrofuran; methanol / 27 h / 20 °C
3.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C
3.2: 0.25 h
4.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C
5.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 20 - 60 °C
6.1: cesium fluoride / bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 20 - 120 °C
7.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
7.2: 25.5 h
With
hydrogen; sodium methylate; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); bis(tri-t-butylphosphine)palladium(0); 20% Pd(OH)2 on carbon;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: methanol; hexane; benzene / 2.25 h / 0 - 20 °C
1.2: 0.25 h
2.1: pyridinium hydrobromide perbromide / tetrahydrofuran; dichloromethane / 2 h / 20 °C
3.1: sodium carbonate; lithium chloride / tetrakis(triphenylphosphine) palladium(0) / ethanol; water; toluene / 20 - 60 °C
4.1: cesium fluoride / bis(tri-t-butylphosphine)palladium(0) / 1,4-dioxane / 20 - 120 °C
5.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
5.2: 25.5 h
With
pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; cesium fluoride; lithium chloride;
tetrakis(triphenylphosphine) palladium(0); bis(tri-t-butylphosphine)palladium(0);
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; benzene;
