Technology Process of 13-cyclohexyl-3-{[2-(morpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy}-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid
There total 9 articles about 13-cyclohexyl-3-{[2-(morpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy}-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
water; potassium hydroxide;
In
1,4-dioxane;
at 20 - 40 ℃;
for 2.5h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: potassium carbonate / acetonitrile / 17 h / 20 °C / Inert atmosphere
2.1: tetrabutylammomium bromide; sodium hydroxide / water; 1,2-dichloro-ethane / 49.5 h / Reflux
3.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
4.2: 18 h / 20 - 100 °C
5.1: palladium 10% on activated carbon; hydrogen / methanol / 1.08 h
6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
6.2: 2 h / 20 - 60 °C
7.1: water; potassium hydroxide / 1,4-dioxane / 2.5 h / 20 - 40 °C
With
palladium 10% on activated carbon; tetrabutylammomium bromide; water; hydrogen; bromine; sodium hydride; potassium carbonate; potassium hydroxide; sodium hydroxide;
In
1,4-dioxane; methanol; diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: boron trifluoride diethyl etherate / 20 °C / Inert atmosphere
2.1: potassium carbonate / acetonitrile / 17 h / 20 °C / Inert atmosphere
3.1: tetrabutylammomium bromide; sodium hydroxide / water; 1,2-dichloro-ethane / 49.5 h / Reflux
4.1: bromine / 1,4-dioxane; diethyl ether / 0.33 h / 20 °C
5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere
5.2: 18 h / 20 - 100 °C
6.1: palladium 10% on activated carbon; hydrogen / methanol / 1.08 h
7.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
7.2: 2 h / 20 - 60 °C
8.1: water; potassium hydroxide / 1,4-dioxane / 2.5 h / 20 - 40 °C
With
palladium 10% on activated carbon; boron trifluoride diethyl etherate; tetrabutylammomium bromide; water; hydrogen; bromine; sodium hydride; potassium carbonate; potassium hydroxide; sodium hydroxide;
In
1,4-dioxane; methanol; diethyl ether; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;
![methyl 13-cyclohexyl-3-{[2-(morpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy}-6,7-dihydropyrazolo[5',1':2,3]imidazo[1,5-d][1,4]benzoxazepine-10-carboxylate](/Databaselist/images/loading.webp)
