N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide
CAS No.:1318756-43-2
Molecular Formula:C₂₁H₁₇Cl₂FN₂O₃S₂
Molecular Weight:499.414
Hs Code.:

Synonyms:N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

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Chemical Property of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

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Technology Process of N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

There total 6 articles about N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1-(4-chloro-benzenesulfonyl)-cyclopropanecarboxylic acid

: 1318757-72-0
tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

: 1318756-43-2
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

Guidance literature:: tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate; With hydrogenchloride; In ethanol; water; at 0 - 50 ℃;

With sodium hydrogencarbonate; sodium hydroxide; In ethanol; water; at 0 ℃; pH=10 - 11;

1-(4-chloro-benzenesulfonyl)-cyclopropanecarboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl acetamide; at 0 - 60 ℃;

Reference yield:

: 493038-93-0
(3-chloro-5-fluorophenyl)acetonitrile

: 1318756-43-2
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2.1: pyridine / ethanol / 72 h / 20 °C

3.1: sodium hydroxide; water / ethanol / 3 h

4.1: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

5.1: hydrogenchloride / ethanol; water / 0 - 50 °C

5.2: 0 °C / pH 10 - 11

5.3: 0 - 60 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate;

Reference yield:

: 493024-39-8
1-(bromomethyl)-3-chloro-5-fluorobenzene

: 1318756-43-2
N-[2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]-1-[(4-chlorophenyl)sulfonyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzyltri(n-butyl)ammonium chloride; acetic acid / toluene; water / 4 h / 20 °C

2.1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

3.1: pyridine / ethanol / 72 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 3 h

5.1: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

6.1: hydrogenchloride / ethanol; water / 0 - 50 °C

6.2: 0 °C / pH 10 - 11

6.3: 0 - 60 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; benzyltri(n-butyl)ammonium chloride; acetic acid; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate; toluene;