tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

Base Information

Chemical Name:tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate
CAS No.:1318757-72-0
Molecular Formula:C₁₆H₁₈ClFN₂O₂S
Molecular Weight:356.849
Hs Code.:

Synonyms:tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

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Chemical Property of tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

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Technology Process of tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

There total 5 articles about tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1318757-71-9
2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazole-5-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1318757-72-0
tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; at 90 ℃; for 2.5h;

Reference yield:

: 493024-39-8
1-(bromomethyl)-3-chloro-5-fluorobenzene

: 1318757-72-0
tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: benzyltri(n-butyl)ammonium chloride; acetic acid / toluene; water / 4 h / 20 °C

2: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

3: pyridine / ethanol / 72 h / 20 °C

4: sodium hydroxide; water / ethanol / 3 h

5: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; benzyltri(n-butyl)ammonium chloride; acetic acid; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; water; ethyl acetate; toluene;

Reference yield:

: 493038-93-0
(3-chloro-5-fluorophenyl)acetonitrile

: 1318757-72-0
tert-butyl [2-(3-chloro-5-fluorobenzyl)-4-methyl-1,3-thiazol-5-yl]carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; O,O-Diethyl hydrogen phosphorodithioate / ethyl acetate / 20 °C

2: pyridine / ethanol / 72 h / 20 °C

3: sodium hydroxide; water / ethanol / 3 h

4: triethylamine; diphenyl phosphoryl azide / 2.5 h / 90 °C

With pyridine; hydrogenchloride; diphenyl phosphoryl azide; water; O,O-Diethyl hydrogen phosphorodithioate; triethylamine; sodium hydroxide; In ethanol; ethyl acetate;