ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

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Chemical Name:ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate
CAS No.:722487-32-3
Molecular Formula:C₂₇H₂₄ClFN₆O₅
Molecular Weight:566.976
Hs Code.:

Synonyms:ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

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Chemical Property of ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

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Technology Process of ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

There total 1 articles about ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 722491-07-8
3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

: 89892-98-8
2-bromomethylcyclopropanecarboxylic acid ethyl ester

: 722487-32-3
ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

Guidance literature:: With potassium carbonate; In ISOPROPYLAMIDE; at 60 ℃; for 18h;

Reference yield: 50.0%

: 722487-32-3
ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate

: 722487-30-1
3-chloro-4-fluoro-N-{5-[(7-{[2-(hydroxymethyl)cyclopropyl]methoxy}-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide

Guidance literature:: ethyl 2-({[4-({2-[(3-chloro-4-fluorobenzoyl)amino]pyrimidin-5-yl}amino)-6-methoxyquinazolin-7-yl]oxy}methyl)cyclopropylcarboxylate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 36h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃;