3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

Base Information

Chemical Name:3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate
CAS No.:722491-07-8
Molecular Formula:C₂HF₃O₂*C₂₀H₁₄ClFN₆O₃
Molecular Weight:554.845
Hs Code.:

Synonyms:3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

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Chemical Property of 3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

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Technology Process of 3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

There total 1 articles about 3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 331792-39-3
N-(5-{[7-(benzyloxy)-6-methoxyquinazolin-4-yl]amino}pyrimidin-2-yl)-3-chloro-4-fluorobenzamide

: 76-05-1
trifluoroacetic acid

: 722491-07-8
3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

Guidance literature:: for 2h; Heating / reflux;

Reference yield: 86.0%

: 722491-07-8
3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate

: 76-05-1
trifluoroacetic acid

: 166815-96-9
N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine

: 3-chloro-4-fluoro-N-(5-{[6-methoxy-7-(piperidin-4-ylmethoxy)quinazolin-4-yl]amino}pyrimidin-2-yl)benzamide ditrifluoroacetate

Guidance literature:: 3-chloro-4-fluoro-N-{5-[(7-hydroxy-6-methoxyquinazolin-4-yl)amino]pyrimidin-2-yl}benzamide trifluoroacetate; N-tert-butoxycarbonyl-4-(4-toluenesulphonyloxymethyl)piperidine; With potassium carbonate; In ISOPROPYLAMIDE; at 60 ℃; for 18h;

trifluoroacetic acid; In dichloromethane; at 20 ℃; for 5h;