N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

Base Information

Chemical Name:N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide
CAS No.:1269662-85-2
Molecular Formula:C₂₃H₂₇ClFN₄O₆P
Molecular Weight:540.916
Hs Code.:

Synonyms:N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

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Chemical Property of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

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Technology Process of N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

There total 3 articles about N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.5%

: 3095-95-2
diethylphosphonoacetic acid

N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine: 402855-01-0
N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine

: 1269662-85-2
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: diethylphosphonoacetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 50 ℃; for 1.5h;

N⁴-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)quinazoline-4,6-diamine; In tetrahydrofuran; at 40 - 50 ℃; for 3h;

Reference yield:

: 162012-67-1
N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

: 1269662-85-2
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide / 2 h / 40 °C / Cooling with ice

1.2: 16 h / 40 - 50 °C

2.1: acetic acid; iron / 4 h / Reflux

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 50 °C

3.2: 3 h / 40 - 50 °C

With iron; sodium hydride; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dimethyl sulfoxide;

Reference yield:

: 402855-06-5
N-(3-chloro-4-fluorophenyl)-7-(2-methoxyethoxy)-6-nitroquinazoline-4-amine

: 1269662-85-2
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-(2-methoxyethoxy)quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid; iron / 4 h / Reflux

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 1.5 h / 50 °C

2.2: 3 h / 40 - 50 °C

With iron; acetic acid; 1,1'-carbonyldiimidazole; In tetrahydrofuran;