(S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

Base Information

• Chemical Name: (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate
• CAS No.: 1351166-50-1
• Molecular Formula: C₂HF₃O₂*C₂₃H₂₉F₂N₅O₃S
• Molecular Weight: 607.602
• Mol file: 1351166-50-1.mol

Synonyms:(S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

Chemical Property of (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate

There total 11 articles about (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(methylamino)pyrrolidin-2-one (1351168-15-4) + trifluoroacetic acid (76-05-1) + 1,2,4-trifluoro-5-(methylsulfonyl)benzene (845616-49-1) → (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate (1351166-50-1)

Guidance literature:

(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(methylamino)pyrrolidin-2-one; 1,2,4-trifluoro-5-(methylsulfonyl)benzene; With sodium carbonate; In dimethyl sulfoxide; at 130 ℃; for 18h; Sealed tube;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

2-chloro-5-ethylpyrimidine (111196-81-7) → (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate (1351166-50-1)

Guidance literature:

Multi-step reaction with 8 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 18 h / 100 °C / Sealed tube

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 18 h / 20 °C

4.1: 18 h / 20 °C

5.1: sodium hydride / dichloromethane; N,N-dimethyl-formamide; mineral oil / 1.08 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 0.5 h

7.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

8.1: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Sealed tube

With sodium hydride; sodium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

2,4,5-trifluorobenzene-1-sulfonyl chloride (220227-21-4) → (S)-3-((2,5-difluoro-4-(methylsulfonyl)phenyl)(methyl)amino)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyrrolidin-2-one trifluoroacetate (1351166-50-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydroxide; sodium sulfite / water / pH 14

1.2: pH ~ 1 / Cooling with ice

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: sodium carbonate / dimethyl sulfoxide / 18 h / 130 °C / Sealed tube

With sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; sodium sulfite; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;

upstream raw materials:

(S)-1-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-(methylamino)pyrrolidin-2-one

trifluoroacetic acid

1,2,4-trifluoro-5-(methylsulfonyl)benzene

2-chloro-5-ethylpyrimidine