N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide

Base Information

• Chemical Name: N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide
• CAS No.: 848853-42-9
• Molecular Formula: C₂₇H₂₆BrNO₃
• Molecular Weight: 492.412

Synonyms:N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide

Chemical Property of N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide

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Technology Process of N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide

There total 1 articles about N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-[(3'-bromo-4'-methoxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide (848853-41-8) → N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide (848853-42-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 0 ℃; for 2h;

Reference yield: 95.0%

N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide (848853-42-9) + cyanomethyl bromide (590-17-0) → N-{[3'-bromo-4'-(cyanomethoxy)-1,1'-biphenyl-4-yl]methyl}-2-butyl-N-methyl-1-benzofuran-3-carboxamide (848853-43-0)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 23h;

Reference yield: 93.0%

N-[(3'-bromo-4'-hydroxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide (848853-42-9) + bromoacetic acid methyl ester (96-32-2) → methyl [(3-bromo-4'-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)-amino]methyl}-1,1'-biphenyl-4-yl)oxy]acetate (848853-45-2)

Guidance literature:

With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 23h;

upstream raw materials:

N-[(3'-bromo-4'-methoxy-1,1'-biphenyl-4-yl)methyl]-2-butyl-N-methyl-1-benzofuran-3-carboxamide

Downstream raw materials:

N-{[3'-bromo-4'-(cyanomethoxy)-1,1'-biphenyl-4-yl]methyl}-2-butyl-N-methyl-1-benzofuran-3-carboxamide

methyl [(3-bromo-4'-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)-amino]methyl}-1,1'-biphenyl-4-yl)oxy]acetate

methyl 2-[(3-bromo-4'-{[[(2-butyl-1-benzofuran-3-yl)carbonyl](methyl)-amino]methyl}-1,1'-biphenyl-4-yl)oxy]-3-phenylpropanoate

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