(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

Base Information

Chemical Name:(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate
CAS No.:1322592-04-0
Molecular Formula:C₂₄H₂₁FO₆S₂
Molecular Weight:488.558
Hs Code.:

Synonyms:(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

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Technology Process of (R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

There total 7 articles about (R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 910650-82-7
1-fluoro-1,1-bis(phenylsulfonyl)methane

: 956833-12-8
methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate

: 1322592-04-0
(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

Guidance literature:: With C₅₄H₅₆N₄O₆; In 1,1,1-trifluorotoluene; at 40 ℃; for 72h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/anie.201103748

Reference yield: 90.0%

: 1322591-84-3
(R)-methyl 2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

: 1322592-04-0
(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

Guidance literature:: (R)-methyl 2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

With Selectfluor; In acetonitrile; at 70 ℃; for 14h; optical yield given as %ee;
DOI:10.1039/c1ob06308a

Reference yield:

: 910650-82-7
1-fluoro-1,1-bis(phenylsulfonyl)methane

: 956833-12-8
methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate

: 1352637-34-3
(S)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

: 1322592-04-0
(R)-methyl 4-fluoro-2-methylene-3-phenyl-4,4-bis(phenylsulfonyl)butanoate

Guidance literature:: With hydroquinidine (anthraquinone-1,4-diyl) diether; In α,α,α-trifluorotoluene; at 50 ℃; for 13h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/chem.201100929