trans-1-benzyl-4--2-piperidinecarbonitrile

Base Information

Chemical Name:trans-1-benzyl-4--2-piperidinecarbonitrile
CAS No.:116787-76-9
Molecular Formula:C₂₂H₂₃N₃O₃
Molecular Weight:377.443
Hs Code.:

trans-1-benzyl-4-<o-nitrophenyl)acetonyl>-2-piperidinecarbonitrile

Synonyms:trans-1-benzyl-4--2-piperidinecarbonitrile

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Chemical Property of trans-1-benzyl-4--2-piperidinecarbonitrile

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Technology Process of trans-1-benzyl-4--2-piperidinecarbonitrile

There total 4 articles about trans-1-benzyl-4--2-piperidinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 151-50-8
potassium cyanide

: 116787-78-1
1-(1-benzyl-4-piperydyl)-3-(o-nitrophenyl)-2-propanone

: 116787-76-9
trans-1-benzyl-4--2-piperidinecarbonitrile

Guidance literature:: With trifluoroacetic anhydride; 3-chlorobenzoate; In dichloromethane; water; 1.) 0 deg C, 1 h; 2.) -15 deg C, 1h, up to rt, 15 min;
DOI:10.1016/S0040-4020(01)90353-9

Reference yield:

: 106140-31-2
methyl 1-benzyl-4-piperidineacetoacetate

: 116787-76-9
trans-1-benzyl-4--2-piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 44 percent / potassium tert-butoxide / hexamethylphosphoric acid triamide / 2 h / 60 - 70 °C

2: 86 percent / 3 N HCl / 3 h / Heating

3: 70 percent / 1.) m-chlorobenzoic acid; 2.) trifluoroacetic anhydride / CH₂Cl₂; H₂O / 1.) 0 deg C, 1 h; 2.) -15 deg C, 1h, up to rt, 15 min

With hydrogenchloride; potassium tert-butylate; trifluoroacetic anhydride; 3-chlorobenzoate; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;
DOI:10.1016/S0040-4020(01)90353-9

Reference yield:

: 116787-77-0
methyl 1-benzyl-α-(o-nitrophenyl)-4-piperidineacetoacetate

: 116787-76-9
trans-1-benzyl-4--2-piperidinecarbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / 3 N HCl / 3 h / Heating

2: 70 percent / 1.) m-chlorobenzoic acid; 2.) trifluoroacetic anhydride / CH₂Cl₂; H₂O / 1.) 0 deg C, 1 h; 2.) -15 deg C, 1h, up to rt, 15 min

With hydrogenchloride; trifluoroacetic anhydride; 3-chlorobenzoate; In dichloromethane; water;
DOI:10.1016/S0040-4020(01)90353-9