tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate

Base Information

• Chemical Name: tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate
• CAS No.: 865291-63-0
• Molecular Formula: C₃₇H₄₅N₅O₄Si
• Molecular Weight: 651.881
• Mol file: 865291-63-0.mol

Synonyms:tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate

Chemical Property of tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate

There total 1 articles about tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-Butyl (3-{[(5-bromo-1-(2-trimethylsilyl-ethoxymethyl)-1H-indazol-3-yl)carbonyl]amino}benzyl)ethyl-carbamate (865291-61-8) + 4-isoquinolineboronic acid (192182-56-2) → tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate (865291-63-0)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 80 ℃; for 20h;

Reference yield:

tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate (865291-63-0) → N-{3-[(Ethylamino)methyl]phenyl}-5-isoquinolin-4-yl-1H-indazole-3-carboxamide dihydrochloride

Guidance literature:

tert-Butyl ethyl(3-{[(5-isoquinolin-4-yl-1-(2-trimethylsilylethoxymethyl)-1H-indazol-3-yl)carbonyl]-amino}benzyl)carbamate; With trifluoroacetic acid; at 4 - 20 ℃; for 2h;

With ethylenediamine; In tetrahydrofuran; at 70 ℃;

With hydrogenchloride; In isopropyl alcohol;

upstream raw materials:

tert-Butyl (3-{[(5-bromo-1-(2-trimethylsilyl-ethoxymethyl)-1H-indazol-3-yl)carbonyl]amino}benzyl)ethyl-carbamate

4-isoquinolineboronic acid